After 10 years, members of the 4D Nucleome consortium have successfully completed the first phase of a project that aims to ...

Cr yo-ET captured dozens of projection images of each slice from different angles. Computational processing then stitched those projections into detailed 3D views of the condensates and their ...

There is a huge amount of DNA in most human cells, and that DNA has to be carefully compacted and organized so that it will ...

High-resolution imaging has revealed the internal layout of chromatin condensates, showing how DNA fibers fold and interact ...

Much the way the caps on the ends of a shoelace prevent it from fraying, telomeres - regions of repetitive DNA sequences and a protein structure - protect the tips of chromosomes from damage. Every ...

A deeper understanding of how DNA changes over generations helps scientists learn why people differ and how diseases develop. Until recently, many fast-changing parts of the human genome remained ...

When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication process can cause alterations in genomic DNA, promoting cellular ageing, cancer, ...