Nucleotide excision repair (NER) is a major conserved DNA repair pathway, which repairs various types of damage in the genome, such as those induced by ultraviolet light and environmental agents.
The most frequent DNA lesions (8-oxoguanine, thymine glycol, dihydrothymine, dU) (De Bont and van Larebeke, 2014) are removed from the genome by the BER (Kim and Wilson, 2012) (Figure 1). This repair ...
The parametric estimation procedure to predict long-term efficacy on survival from publication data of clinical trials for metastatic colorectal cancer (mCRC). This is an ASCO Meeting Abstract from ...
The excision repair cross-complementation group 1 (ERCC1) protein is a potential prognostic biomarker of the efficacy of cisplatin-based chemotherapy in non–small-cell lung cancer (NSCLC). Although ...
Damage to your DNA is unavoidable. Every day our cells are bombarded by gene-splitting UV radiation or chemical carcinogens. Regular water inside our bodies can cause DNA damage. DNA damage is as ...
Maintaining the stability of the genome is essential for all organisms, and it is not surprising that damage to DNA has been proposed as an explanation for multiple chronic diseases. 1–5 Conserving a ...
A researcher has made a discovery that alters our understanding of how the body's DNA repair process works and may lead to new chemotherapy treatments for cancer and other disorders. Researchers ...
Identifying the molecular repair kits that cells use to fix damaged DNA has won three scientists the 2015 Nobel Prize in chemistry. Tomas Lindahl of the Francis Crick Institute in England, Paul ...
A study has uncovered new findings about a DNA repair pathway called nucleotide excision repair and its role in the development of cancer. The paper also details how this defective pathway could be ...
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